Endocrine Abstracts

Background: Pembrolizumab is a novel anti-cancer drug that targets programmed cell death protein 1 (PD-1) receptor on lymphocytes resulting in their activation against tumor cells. PD-1 receptors are also distributed in endocrine organs and pembrolizumab use has long-been associated with hypophysitis and thyroiditis. We describe a patient with pembrolizumab-induced thyroiditis who developed an uncommon fulminant Type 1 Diabetes Mellitus (FT1D).Case prese...

Case Presentation: 37-year-old woman of South Asian origin was referred from retinopathy screening to our diabetes clinic for evaluation of an unusual finding during her retinal screen. Her retinal blood vessels appeared white in contrast to normal pink to red colour. She was recently diagnosed with type 2 diabetes and with type 1 hyperlipidaemia (T1 HPLA) confirmed by genotype for more than 10 years for which she had suboptimal control with multiple hospitalisations with recu...

Introduction: Older age and diabetes are both risk factors for frailty. Functional decline and disability in older, frail adults with diabetes results in an increased susceptibility to falls and hospital admission. Hypoglycaemia is common and more likely to result in hospital admission in older adults with diabetes and frailty. An HbA1c of below 7% (53 mmol/mol) is likely to represent overtreatment of hyperglycaemia. JBDS has recommended a review of HbA1c...

Background: Although pheochromocytoma classically presents with headaches, palpitations and paroxysmal hypertension, uncommon presentations such as cardiomyopathy, stroke and subarachnoid haemorrhage have been documented. We present one such infrequent presentation of myocardial infarction with normal coronary arteries (MINOCA).Case presentation: A 79-year Caucasian female presented with central crushing chest pain radiating to left arm associated with h...

Background: Effective management of diabetic ketoacidosis (DKA) improves clinical outcomes. Regular auditing and performance feedback are key to achieving sustained and significant improvement in the management of DKA. One of the major limitations for maximal impact of an audit is the delay from initiation to results as the latter may not be applicable to the then current practice. In order to overcome this, we created an automated auditing system called Digital Evaluation of ...

IntroductionRecently, apart from its main physiologic role, the active form of vitamin D has also been recognised to have anti-inflammatory and immune-modulating properties. Accumulating evidence suggests that Vitamin D deficiency is associated with increased prevalence of various autoimmune diseases, and in particular, with autoimmune thyroid disease. Despite contradicting evidence, the balance is tipping towards inverse correlation between vitamin D de...

Section 1: Case history: A 37-year-old South Asian woman was referred to our diabetes clinic from the Diabetes Eye Screening Programme. Her retinal blood vessels appeared white, in contrast to the normal pink-red colour. The patient was diagnosed with diabetes secondary to chronic pancreatitis a year prior to this presentation, for which she was on metformin and long-acting insulin but had suboptimal control and multiple hospitalisations with chronic pancreatitis. She was prev...

Introduction: Effective management of diabetic ketoacidosis (DKA) improves clinical outcomes. We created an automated auditing system, Digital evaluation of ketosis and other diabetes emergencies (DEKODE), which identifies DKA episodes based on fixed-rate intravenous insulin infusion (FRIII) prescription.Aim: We validated DEKODE for its ability to audit DKA management against manually collected data.Methods: All episodes identified...

Introduction: Obesity is a global health challenge with more than 60% of the world´s population with obesity living in LMICs. Studies have demonstrated that women are more affected by obesity than men. However, the risk of obesity and obesity-related cardiometabolic diseases in women in LMICs have not been documented. The aims of this meta-analysis are: to evaluate the risk of obesity and obesity-related cardiometabolic disease in women compared to men in LMICs and to eva...

IntroductionOnce thought to typify type 1 diabetes mellitus (T1DM), diabetic ketoacidosis (DKA) in people with type 2 diabetes mellitus (T2DM) is also now increasingly recognized. We explored the clinical and biochemical differences in DKA in the two types of diabetes.MethodsThis retrospective cohort study included all the DKA episodes from April 2014 to September 2020 at a large tertiary care centre in West ...